2,2-Bis(4-fluorophenyl)acetic acid → N-{3-[4-(3-{[(dimethylamino)carbonyl]amino}phenyl)-1-piperidinyl]propyl}-2,2-bis(4-fluorophenyl)acetamide
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:19][CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH:26]([C:29]2[CH:30]=[C:31]([NH:35][C:36](=[O:40])[N:37]([CH3:39])[CH3:38])[CH:32]=[CH:33][CH:34]=2)[CH2:25][CH2:24]1>>[CH3:39][N:37]([CH3:38])[C:36]([NH:35][C:31]1[CH:30]=[C:29]([CH:26]2[CH2:27][CH2:28][N:23]([CH2:22][CH2:21][CH2:20][NH:19][C:9](=[O:11])[CH:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH2:24][CH2:25]2)[CH:34]=[CH:33][CH:32]=1)=[O:40]Participants
3
Procedure
Example 139 was prepared from bis(4-fluorophenyl)acetic acid and N′-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-N,N-dimethylurea according to the procedures described in Scheme 9: ESMS m/e: 535.4 (M+H)+.
Sources & evidence
- ORD record
- ord-2fb648812c3145fc82e14f1605d6f845
- Source dataset
- uspto-grants-2006_09
- Patent number
- US07105544B2
Reaction notes
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