Methylamine → 4-Methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

Participants

Reaction Conditions

Reaction Steps

At room temperature, 144 g (0.576 mol) of 2-chloro-4-methyl-1,3-thiazole-5-sulphonamide are initially charged in 600 ml of acetonitrile, and 147 g (1.9 mol) of a 40% strength aqueous methylamine solution are metered in at room temperature. The reaction mixture is stirred at 50° C. for 6 h and then concentrated using a rotary evaporator. The residue is admixed with water, filtered off with suction and dried.

Provenance & Evidence