Methylamine → 4-Methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

HRID 2213525Notes

Reaction equation

HRID 2213525 reaction equation
Cl[C:2]1[S:3][C:4]([S:8]([NH2:11])(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1.[CH3:12][NH2:13]>C(#N)C>[CH3:7][C:5]1[N:6]=[C:2]([NH:13][CH3:12])[S:3][C:4]=1[S:8]([NH2:11])(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 120942512-Chloro-4-methyl-1,3-thiazole-5-sulfonamide

Product 1

HCID 112757814-Methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

At room temperature, 144 g (0.576 mol) of 2-chloro-4-methyl-1,3-thiazole-5-sulphonamide are initially charged in 600 ml of acetonitrile, and 147 g (1.9 mol) of a 40% strength aqueous methylamine solution are metered in at room temperature. The reaction mixture is stirred at 50° C. for 6 h and then concentrated using a rotary evaporator. The residue is admixed with water, filtered off with suction and dried.

Workup

  1. customare metered in at room temperature
  2. concentrationconcentrated
  3. customa rotary evaporator
  4. filtrationfiltered off with suction
  5. customdried

Sources & evidence

ORD record
ord-dcdbc976b04947678d9923e5d66156e6
Source dataset
uspto-grants-2006_09
Patent number
US07105553B2

Reaction notes

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