反应详情

Trifluoroacetic acid (20 ml) was added to a stirred solution of 4-(3-pyridin-4-yl-[1,2,4]oxadiazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester (Example 2, 1.64 g, 4.96 mmol) in CH2Cl2 (35 ml). After 2.5 h at rt, the solvent was evaporated under reduced pressure. The residual solid was suspended in EtOAc (150 ml) and washed with saturated aqueous Na2CO3 (20 ml). The aqueous was separated and extracted with EtOAc (3×30 ml). The combined organic extracts were dried (MgSO4) and evaporated under reduced pressure to afford the title compound: RT=3.48 min, m/z (ES+)=231.2 [M+H]+.

1. customthe solvent was evaporated under reduced pressure
2. washwashed with saturated aqueous Na2CO3 (20 ml)
3. customThe aqueous was separated
4. extractionextracted with EtOAc (3×30 ml)
5. dry with materialThe combined organic extracts were dried (MgSO4)
6. customevaporated under reduced pressure