HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propyl isocyanate → 4-(3-Pyridin-4-yl-[1,2,4]oxadiazol-5-yl)piperidine-1-carboxylic acid propylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propyl isocyanate | HCID 61033 | — |
| Reactant | 4-(5-Piperidin-4-yl-1,2,4-oxadiazol-3-yl)pyridine | HCID 2761143 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-Pyridin-4-yl-[1,2,4]oxadiazol-5-yl)piperidine-1-carboxylic acid propylamide | HCID 11472520 | — |
Reaction Steps
1-Propylisocyanate (13 μl, 137 μmol) was added to a solution of 4-(5-piperidin-4-yl-[1,2,4]oxadiazol-3-yl)pyridine (Example 51, 15.8 mg, 691 mol) in CH2Cl2 (0.7 ml). After stirring 18 h at rt, the solvent was removed to afford the title compound: RT=2.72 min; m/z (ES+)=316.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207147B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-920a4f51cb324934aa8113c6ef28fbb9 |
| Source note | uspto-grants-2012_06 |