2,6-Diisopropylphenyl isocyanate → N'-(2,6-diisopropylphenyl)-N-[(4-dimethylaminophenyl)methyl]-N-(4-trifluoromethylphenyl)urea

HRID 2213654Notes

Reaction equation

HRID 2213654 reaction equation
[CH3:1][N:2]([CH3:21])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.[CH:22]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]([CH3:33])[CH3:32])[C:26]=1[N:34]=[C:35]=[O:36])([CH3:24])[CH3:23]>>[CH:22]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]([CH3:32])[CH3:33])[C:26]=1[NH:34][C:35](=[O:36])[N:10]([CH2:9][C:6]1[CH:5]=[CH:4][C:3]([N:2]([CH3:21])[CH3:1])=[CH:8][CH:7]=1)[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:13][CH:12]=1)([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 922592,6-Diisopropylphenyl isocyanateHCID 21957911[(4-Dimethylaminophenyl)methyl](4-trifluoromethylphenyl)amine

Product 1

HCID 21957953N'-(2,6-diisopropylphenyl)-N-[(4-dimethylaminophenyl)methyl]-N-(4-trifluoromethylphenyl)ureaYield 13.6%

Procedure

By the reaction and treatment in the same manner as in Example 1 using [(4-dimethylaminophenyl)methyl](4-trifluoromethylphenyl)amine (1.0 g) and 2,6-diisopropylphenyl isocyanate (0.83 g) as starting materials, N′-(2,6-diisopropylphenyl)-N-[(4-dimethylaminophenyl)methyl]-N-(4-trifluoromethylphenyl)urea (0.23 g) was obtained. melting point: 129–130° C.

Sources & evidence

ORD record
ord-05ccdf48101b4af1bd82ad7ed075923e
Source dataset
uspto-grants-2006_09
Patent number
US07105567B2

Reaction notes

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