Hydrochloric Acid → HCID 21957963, compound

HRID 2213657Notes

Reaction equation

HRID 2213657 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][N:15]([CH2:17][C:18]3[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=3)[CH:16]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH:25]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH:34]([CH3:36])[CH3:35])[C:29]=1[N:37]=[C:38]=[O:39])([CH3:27])[CH3:26].[ClH:40].Cl.C(OCC)(=O)C>>[ClH:40].[CH:25]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH:34]([CH3:35])[CH3:36])[C:29]=1[NH:37][C:38](=[O:39])[N:10]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=1)[CH2:11][C:12]1[CH:13]=[N:14][N:15]([CH2:17][C:18]2[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=2)[CH:16]=1)([CH3:26])[CH3:27]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 922592,6-Diisopropylphenyl isocyanateHCID 21866389Hydrogen chloride-ethyl acetateHCID 21957957HCID 21957957, compound

Product 1

HCID 21957963HCID 21957963, compound

Procedure

In the same manner as in Example 62, reaction and treatment were conducted using (4-isopropylphenyl)({1-[(4-methyl-2-pyridyl)methyl]pyrazol-4-yl}methyl)amine (0.42 g) and 2,6-diisopropylphenyl isocyanate (0.42 mL) as starting materials. Further, the obtained oil compound was converted to hydrochloride with 4N hydrochloric acid-ethyl acetate to give N′-(2,6-diisopropylphenyl)-N-(4-isopropylphenyl)-N-({1-[(4-methyl-2-pyridyl)methyl]pyrazol-4-yl}methyl)urea hydrochloride (0.33 g).

Workup

  1. customIn the same manner as in Example 62, reaction and treatment

Sources & evidence

ORD record
ord-a5f5b57317124437be840b03cf8d599f
Source dataset
uspto-grants-2006_09
Patent number
US07105567B2

Reaction notes

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