1-Bromopropane → HCID 66673967, compound

HRID 221366Notes

Reaction equation

HRID 221366 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:11]=[C:10]([C@@H:12]3[CH2:16][CH2:15][C@H:14]([CH2:17][OH:18])[CH2:13]3)[O:9][N:8]=2)=[CH:3][CH:2]=1.Br[CH2:20][CH2:21][CH3:22]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:20]([O:18][CH2:17][C@@H:14]1[CH2:15][CH2:16][C@H:12]([C:10]2[O:9][N:8]=[C:7]([C:4]3[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=3)[N:11]=2)[CH2:13]1)[CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 78401-BromopropaneHCID 57954443HCID 57954443, compound

Product 1

HCID 66673967HCID 66673967, compound

Reagents, catalysts & solvents 1

HCID 67553Tetrabutylammonium IodideCatalyst

Procedure

cis-[3-(3-Pyridin-4-yl-[1,2,4]oxadiazol-5-yl)cyclopentyl]methanol (Preparation 5) was reacted with 1-bromopropane in the presence of tetrabutylammonium iodide, using a similar procedure to that described in Example 106, to afford the title compound: RT=3.69 min, m/z (ES+)=288.3 [M+H]+.

Sources & evidence

ORD record
ord-bf257288622f49f589930e653a745181
Source dataset
uspto-grants-2012_06
Patent number
US08207147B2

Reaction notes

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