反应详情

4-Acetylimidazole (0.7 g, 3.1 mmol) and 5-nitroindolin-2-one (0.56 g, 3.1 mmol) in sealed tube were heated in the presence of piperidine at 135° C. After 30 minutes, the reaction mixture was cooled to ambient temperature and concentrated. Recrystallization from ethanol afforded 0.66 g of 5-nitro-3-[1-(imidazol-4-yl)ethylidene]indolin-2-one.

1. concentrationconcentrated
2. customRecrystallization from ethanol