反应详情

A mixture of 1.22 g (4.49 mmol) of 4-hydroxy-8-nitrobenzo[4,5]thieno[3,2-b]pyridine-3-carbonitrile in 20 mL of phosphorous oxychloride is heated at reflux temperature for 3 hours, then cooled to room temperature. The solid is collected by filtration, then washed with hexane followed by water. The solid is dried to give 947 mg (73%) of a dark brown solid, mp softens at 270° C.

1. temperatureis heated
2. temperatureat reflux temperature for 3 hours
3. filtrationThe solid is collected by filtration
4. washwashed with hexane
5. customThe solid is dried