HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 2-(4,5-Dimethoxy-2-hydroxyphenyl)-4-(2-pyridylmethyl) aminomethylbenzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Pyridinemethanamine | HCID 19509 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Amino-m-cresol | HCID 3014138 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4,5-Dimethoxy-2-hydroxyphenyl)-4-(2-pyridylmethyl) aminomethylbenzoxazole | HCID 135428694 | — |
Reaction Steps
BBr3 in CH2Cl2, rt (b) CH2OCH2Cl, TEA in CH2Cl2, rt (c) amino-m-cresol in benzene, reflux (d) BaMnO4 in benzene, reflux (e) NBS, AIBN in CCl4, reflux (f) 2-aminomethylpyridine derivative, K2CO3 in CH3CN, rt (g) TsOH in CH3OH, rt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105680B1 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-4c1f1f7c726e4bfb9adaa0a0ecc2be25 |
| Source note | uspto-grants-2006_09 |