反应详情

温度

0 °C

2-Hydroxy-2-(3-nitrophenyl)ethyl acetate (18 g) was dissolved in MeOH (180 mL) and cooled to 0° C. K2CO3 (22 g) was added and the reaction stirred at room temperature for 2 hours. The mixture was concentrated under vacuum, quenched by addition of water (100 mL) and extracted with ethyl acetate (2×100 mL). The EtOAc layer was dried over Na2SO4 and concentrated to give the crude title compound (13 g, 88%).

1. concentrationThe mixture was concentrated under vacuum
2. customquenched by addition of water (100 mL)
3. extractionextracted with ethyl acetate (2×100 mL)
4. dry with materialThe EtOAc layer was dried over Na2SO4
5. concentrationconcentrated