Benzyl Bromide → 1-Benzyl-1H-pyrazole

HRID 2214412노트

반응식

HRID 2214412 반응식
I[C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.[H-].[Na+].[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CN(C=O)C>[CH2:9]([N:4]1[CH:3]=[CH:2][CH:6]=[N:5]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 770224-Iodopyrazole

생성물 1

HCID 35464411-Benzyl-1H-pyrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-iodopyrazole (400 mg, 2 mmol) in DMF(4 mL) at 0 C was added sodiumhydride (80 mg, 60% dispersion in mineral oil, 2 mmol) followed by benzyl bromide (342 mg, 2 mmol) and reaction mixture was allowed to stir for 2 h. Reaction mixture was concentrated in vacuo and the residue was purified by column chromatography to give N-benzylpyrazole in almost quantitative yield. 1H NMR 5.29 (s, 2H), 7.18–7.28 (m,2H), 7.28–7.40 (m, 4H), 7.53 (s, 1H).

후처리

  1. customReaction mixture
  2. concentrationwas concentrated in vacuo
  3. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-94d7207121064285bf74c012fd369b71
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109180B2

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