1,1'-Thiocarbonyldiimidazole → HCID 178515271, compound

HRID 2214436Notes

Reaction equation

HRID 2214436 reaction equation
C1N=CN([C:6](N2C=NC=C2)=[S:7])C=1.[NH2:13][C:14]1[C:15](=[O:32])[N:16]([CH2:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=2)[N:17]=[CH:18][C:19]=1[NH2:20]>O1CCCC1>[SH:7][C:6]1[NH:13][C:14]2[C:15](=[O:32])[N:16]([CH2:21][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=[CH:24][CH:23]=3)[N:17]=[CH:18][C:19]=2[N:20]=1

Participants

4

Reactant 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 21947635HCID 21947635, compound

Product 1

HCID 178515271HCID 178515271, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4.99 g (28.0 mmol) of N,N′-thiocarbonyldiimidazole were added to a solution of 4.4 g (16.5 mmol) of 4,5-diamino-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one in 100 ml of tetrahydrofuran and stirred overnight at ambient temperature. Then the mixture was concentrated by evaporation in vacuo, the residue was combined with approx. 30 ml of water, made weakly acidic with hydrochloric acid, the product precipitated was suction filtered, washed with water and dried.

Workup

  1. concentrationThen the mixture was concentrated by evaporation in vacuo
  2. customthe product precipitated
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-69db2b16c4b34876a56ee4f28cc5d647
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

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