Methyl iodide → HCID 178503361, compound

HRID 2214437Notes

Reaction equation

HRID 2214437 reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].IC.[SH:9][C:10]1[NH:11][C:12]2[C:17](=[O:18])[N:16]([CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][CH:21]=3)[N:15]=[CH:14][C:13]=2[N:30]=1>ClCCl.CO>[CH3:1][S:9][C:10]1[NH:11][C:12]2[C:17](=[O:18])[N:16]([CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][CH:21]=3)[N:15]=[CH:14][C:13]=2[N:30]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178515271HCID 178515271, compound

Product 1

HCID 178503361HCID 178503361, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

2.38 g (17.2 mmol) of potassium carbonate and 1.07 ml (17.20 mmol) of iodomethane were added to a suspension of 5.3 g (17.19 mmol) of 2-mercapto-5-(naphthalen-1-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one in 100 ml of dichloromethane and 100 ml of methanol and stirred overnight at ambient temperature. Then the solvent was evaporated off, the residue was combined with approx. 30 ml of water, acidified with 2N hydrochloric acid, the product thus obtained was suction filtered, washed again with water and dried.

Workup

  1. customThen the solvent was evaporated off
  2. customthe product thus obtained
  3. filtrationfiltered
  4. washwashed again with water
  5. customdried

Sources & evidence

ORD record
ord-d712127ca0124bb9bd873c5f39cb39fc
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

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