Dimethyl Sulfoxide → 4-Amino-3-nitropyridin-2-ol

HRID 2214443Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2214443
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](Cl)[C:3]=1[N+:9]([O-:11])=[O:10].CS(C)=[O:14]>O>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([OH:14])[C:3]=1[N+:9]([O-:11])=[O:10]

Komponenten

4

Edukt 2

HCID 679Dimethyl SulfoxideHCID 109650142-Chloro-3-nitropyridin-4-amine

Produkt 1

HCID 1785079054-Amino-3-nitropyridin-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 18.0 g (104 mmol) of 4-amino-2-chloro-3-nitropyridine in 120 ml dimethylsulphoxide and 30 ml of water was stirred for four hours at 130° C. The solution was then cooled and left to stand overnight while cooling with ice. The product that crystallised out was suction filtered, washed with a little water and dried at 50° C.

Aufarbeitung

  1. temperatureThe solution was then cooled
  2. waitleft
  3. temperaturewhile cooling with ice
  4. customThe product that crystallised out
  5. filtrationfiltered
  6. washwashed with a little water
  7. customdried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-0d02813372554639ac88b95362e22626
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109192B2

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