Dimethyl Sulfoxide → 4-Amino-3-nitropyridin-2-ol

Participants

Reaction Steps

A solution of 18.0 g (104 mmol) of 4-amino-2-chloro-3-nitropyridine in 120 ml dimethylsulphoxide and 30 ml of water was stirred for four hours at 130° C. The solution was then cooled and left to stand overnight while cooling with ice. The product that crystallised out was suction filtered, washed with a little water and dried at 50° C.

Provenance & Evidence