Methyl iodide → HCID 178503354, compound

HRID 2214450Notes

Reaction equation

HRID 2214450 reaction equation
[CH2:1]([N:8]1[CH:13]=[CH:12][C:11]2[N:14]=[C:15]([SH:17])[NH:16][C:10]=2[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](=O)([O-])[O-].[K+].[K+].IC>ClCCl.CO>[CH2:1]([N:8]1[CH:13]=[CH:12][C:11]2[N:14]=[C:15]([S:17][CH3:19])[NH:16][C:10]=2[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178515270HCID 178515270, compound

Product 1

HCID 178503354HCID 178503354, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

4.0 g (15.55 mmol) of 5-benzyl-2-mercapto-3,5-dihydro-imidazo[4,5-c]pyridin-4-one were suspended in a mixture of 100 ml of dichloromethane and 50 ml of methanol, then 2.15 g (15.55 mmol) of potassium carbonate and 0.97 ml (15.55 mmol) of iodomethane were added and the mixture was stirred for 1 hour at ambient temperature. Then it was filtered, the filtrate was evaporated down and the residue was further reacted in its crude form.

Workup

  1. filtrationThen it was filtered
  2. customthe filtrate was evaporated down
  3. customthe residue was further reacted in its crude form

Sources & evidence

ORD record
ord-cec4a24149d949dbab537c95939109d8
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

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