Water → HCID 21947639, compound

HRID 2214452Notes

Reaction equation

HRID 2214452 reaction equation
[Mn]([O-])(=O)(=O)=O.[K+].[CH2:7]([N:14]1[CH:19]=[CH:18][C:17]2[N:20]=[C:21]([S:27][CH3:28])[N:22]([CH2:23][C:24]#[C:25][CH3:26])[C:16]=2[C:15]1=[O:29])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.S(=O)(O)[O-:31].[Na+].[OH2:35]>C(O)(=O)C>[CH2:7]([N:14]1[CH:19]=[CH:18][C:17]2[N:20]=[C:21]([S:27]([CH3:28])(=[O:31])=[O:35])[N:22]([CH2:23][C:24]#[C:25][CH3:26])[C:16]=2[C:15]1=[O:29])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 962Water2×HCID 516875Potassium PermanganateHCID 21947668HCID 21947668, compoundHCID 23665763Sodium Bisulfite

Product 1

HCID 21947639HCID 21947639, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 316 mg (2.0 mmol) of potassium permanganate in 10 ml of water was slowly added dropwise with stirring to a solution of 400 mg (1.24 mmol) of 5-benzyl-3-(but-2-ynyl)-2-methylsulphanyl-3,5-dihydro-imidazo[4,5-c]pyridin-4-one in 10 ml of concentrated acetic acid. After three hours at ambient temperature 400 mg of sodium bisulphite (Na2S2O5) were added and the mixture was diluted with approx. 30 ml of water. It was extracted five times with 30 ml of dichloromethane, the extracts were dried over sodium sulphate and evaporated down. The product thus obtained was further reacted without purification.

Workup

  1. extractionIt was extracted five times with 30 ml of dichloromethane
  2. dry with materialthe extracts were dried over sodium sulphate
  3. customevaporated down
  4. customThe product thus obtained
  5. customwas further reacted without purification

Sources & evidence

ORD record
ord-515448b146ab4cafacef79f62ec8dfd6
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

Loading…