反应详情

温度

195 °C

A mixture of (3-chloro-phenyl)-[4-(2-chloro-pyridin-4-yl)-pyrimidin-2-yl]-amine (10.0 g, 0.03 mol) and 2-amino-1-methoxypropane (14.0 g, 0.16 mol) in dioxane (75 ml) is heated in an autoclave at 195° C. for 12 hours. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is separated, dried over magnesium sulfate, filtered and evaporated under reduced presssure. The residue is purified by silicagel chromatography to give the title compound, m.p. 143–144° C.

1. customThe reaction mixture is partitioned between ethyl acetate and water
2. customThe organic phase is separated
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated under reduced presssure
6. customThe residue is purified by silicagel chromatography