Ammonia → HCID 9861036, compound

HRID 2214486Notes

Reaction equation

HRID 2214486 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][N:18]=[C:17](Cl)[CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[NH3:22]>O1CCOCC1>[NH2:22][C:17]1[CH:16]=[C:15]([C:13]2[CH:12]=[CH:11][N:10]=[C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:14]=2)[CH:20]=[CH:19][N:18]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 9905031N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine

Product 1

HCID 9861036HCID 9861036, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
200 °C

Procedure

A suspension of (3-chloro-phenyl)-[4-(2-chloro-pyridin-4-yl)-pyrimidin-2-yl]-amine (10.0 g, 0.03 mol) in dioxane (150 ml) and ammonia (20 g) is heated in an autoclave at 200° C. for 48 hours. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is evaporated under reduced pressure and the product is purified by chromatography on silicagel.

Workup

  1. customThe reaction mixture is partitioned between ethyl acetate and water
  2. customThe organic phase is evaporated under reduced pressure
  3. customthe product is purified by chromatography on silicagel

Sources & evidence

ORD record
ord-c75d79e46c544f4686af96adba361d2c
Source dataset
uspto-grants-2006_09
Patent number
US07109197B2

Reaction notes

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