Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine | HCID 9905031 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 9861036 | HCID 9861036 | — |
Reaction Steps
A suspension of (3-chloro-phenyl)-[4-(2-chloro-pyridin-4-yl)-pyrimidin-2-yl]-amine (10.0 g, 0.03 mol) in dioxane (150 ml) and ammonia (20 g) is heated in an autoclave at 200° C. for 48 hours. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is evaporated under reduced pressure and the product is purified by chromatography on silicagel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07109197B2 |
|---|
| Source dataset | uspto-grants-2006_09 |
|---|
| ORD ID | ord-c75d79e46c544f4686af96adba361d2c |
|---|
| Source note | uspto-grants-2006_09 |
|---|
