O-Methylhydroxylamine hydrochloride → HCID 73855547, compound

HRID 2214575Notes

Reaction equation

HRID 2214575 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.Cl.[O:12]([NH2:14])[CH3:13]>>[CH3:13][O:12][N:14]=[CH:5][C:4]1[CH:7]=[CH:8][C:9]([F:10])=[C:2]([F:1])[CH:3]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 5880883,4-Difluorobenzaldehyde

Product 1

HCID 73855547HCID 73855547, compoundYield 100%

Procedure

Reaction of 3,4-difluorobenzaldehyde with methoxylamine hydrochloride as described in the preparation of Compound 44-A gave the title oxime ether as a clear oil (100% yield). 1HNMR indicated a 85:15 mixture of E- to Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 3.97 (3H, s, OCH3), 7.12–7.26 (2H, m, aromatics), 7.44–7.52 (1H, m, aromatic), 7.97 (1H, s, CH).

Sources & evidence

ORD record
ord-cc745786c2fa4202875c0b3b19c86592
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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