HCID 73855561, compound → HCID 72395082, compound

HRID 2214581Notes

Reaction equation

HRID 2214581 reaction equation
C[C:2]1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([O:20][CH3:21])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=[O:9])[C:4](=[O:22])[O:3]1>CO>[CH3:2][O:3][C:4](=[O:22])[C:5]([OH:6])=[CH:7][C:8](=[O:9])[N:10]([O:20][CH3:21])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1

Participants

3

Reactant 1

HCID 73855561HCID 73855561, compound

Product 1

HCID 72395082HCID 72395082, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-N-methoxy-N-(4-methoxybenzyl)-acetamide was treated with methanol as described in the preparation of Compound 44-D and gave the title ester as white crystals (56% yield); mp 87–89° C. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.67 (3H, s, OCH3), 3.80 (3H, s, OCH3), 3.89 (3H, s, OCH3), 4.77 (2H, s, NCH2), 6.44 (1H, s, CH), 6.87 (2H, m, aromatics), 7.26 (2H, m, aromatics). Anal. calcd for C14H17NO6: C, 56.94; H, 5.80; N, 4.74. Found: C, 57.03; H, 5.82; N, 4.68.

Workup

  1. customas described in the preparation of Compound 44-D

Sources & evidence

ORD record
ord-06800a3399d846a6b9695cf81dd11ef3
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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