2,4-Difluorobenzaldehyde → HCID 73855574, compound

HRID 2214599Notes

Reaction equation

HRID 2214599 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[O:12]([NH2:14])[CH3:13]>>[CH3:13][O:12][N:14]=[CH:4][C:3]1[CH:6]=[CH:7][C:8]([F:10])=[CH:9][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 737702,4-DifluorobenzaldehydeHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 73855574HCID 73855574, compoundYield 80%

Procedure

Reaction of 2,4-difluorobenzaldehyde with methoxylamine hydrochloride as described in the preparation of Compound 44-A gave the title oxime ether as a clear oil (80% yield). 1HNMR indicated a 95:5 mixture of E- and Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 3.98 (3H, s, OCH3), 6.79–6.91 (2H, m, aromatics), 7.79–7.85 (1H, m, aromatic), 8.24 (1H, s, CH).

Sources & evidence

ORD record
ord-6c0902ffb08a4850a31469a182a38ee1
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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