HCID 73855567, compound → HCID 72395069, compound

HRID 2214601Notes

Reaction equation

HRID 2214601 reaction equation
[F:1][C:2]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:3]=1[CH2:4][N:5]([O:17][CH3:18])[C:6](=[O:16])[CH:7]=[C:8]1[C:12](=[O:13])[O:11][C:10](C)(C)[O:9]1>CO>[CH3:10][O:11][C:12](=[O:13])[C:8]([OH:9])=[CH:7][C:6](=[O:16])[N:5]([CH2:4][C:3]1[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:2]=1[F:1])[O:17][CH3:18]

Participants

3

Reactant 1

HCID 73855567HCID 73855567, compound

Product 1

HCID 72395069HCID 72395069, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(2,4-Difluorobenzyl)-2-(2,2-dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-N-methoxy-acetamide was treated with methanol as described in the preparation of Compound 44-D and gave the title ester as white crystals (55% yield); mp 104–105° C. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.73 (3H, s, OCH3), 3.89 (3H, s, OCH3), 4.87 (2H, s, NCH2), 6.45 (1H, s, CH), 6.8–6.9 (2H, m, aromatics), 7.31–7.37 (1H, m, aromatic). Anal. calcd for C13H13F2NO5: C, 51.83; H, 4.35; N, 4.65. Found: C, 51.68; H, 4.27; N, 4.53.

Workup

  1. customas described in the preparation of Compound 44-D

Sources & evidence

ORD record
ord-9d0952042a6a46a19f178e96caddea0e
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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