HCID 73855584, compound → HCID 86760252, compound

HRID 2214606Notes

Reaction equation

HRID 2214606 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[F:24])[CH2:6][N:7]([O:19][CH3:20])[C:8](=[O:18])[CH:9]=[C:10]1[C:14](=[O:15])[O:13][C:12](C)(C)[O:11]1)#[N:2]>CO>[CH3:12][O:13][C:14](=[O:15])[C:10]([OH:11])=[CH:9][C:8](=[O:18])[N:7]([CH2:6][C:5]1[CH:21]=[CH:22][C:23]([F:24])=[C:3]([C:1]#[N:2])[CH:4]=1)[O:19][CH3:20]

Participants

3

Reactant 1

HCID 73855584HCID 73855584, compound

Product 1

HCID 86760252HCID 86760252, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(3-Cyano-4-fluorobenzyl)-2-(2,2-dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-N-methoxy-acetamide was treated with methanol as described in the preparation of Compound 44-D and gave the title ester as white crystals (47% yield); mp 125–126° C. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.75 (3H, s, OCH3), 3.90 (3H, s, OCH3), 4.81 (2H, s, NCH2), 6.44 (1H, s, CH), 7.18 (1H, m, aromatic), 7.56–7.61 (2H, m, aromatics). Anal. calcd for C14H13FN2O5: C, 54.54; H, 4.25; N, 9.08. Found: C, 54.76; H, 4.29; N, 9.04.

Workup

  1. customas described in the preparation of Compound 44-D

Sources & evidence

ORD record
ord-2db0242bdbb142c2b2226d7812a469ac
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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