HCID 73855569, compound → HCID 72395065, compound

HRID 2214620Notes

Reaction equation

HRID 2214620 reaction equation
C[C:2]1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([F:21])[CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:22])[O:3]1>CO>[CH3:2][O:3][C:4](=[O:22])[C:5]([OH:6])=[CH:7][C:8](=[O:9])[N:10]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([F:21])[CH:15]=1)[O:11][CH3:12]

Participants

3

Reactant 1

HCID 73855569HCID 73855569, compound

Product 1

HCID 72395065HCID 72395065, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-N-(3-fluoro-4-methylbenzyl)-N-methoxy-acetamide, prepared using the methods described in the previous examples, was treated with methanol as described in the preparation of Compound 44-C and gave the title ester as white crystals (49% yield); mp 88° C. 1HNMR 400 MHz (CDCl3) δ (ppm): 2.25 (3H, d, J=1.5 Hz, CH3), 3.70 (3H, s, OCH3), 3.90 (3H, s, OCH3), 4.78 (2H, s, NCH2), 6.47 (1H, s, CH), 6.96 (2H, m, aromatics), 7.26 (1H, m, aromatic). HRMS (MAB N2) calculated for C14H16FNO5, [M]+: 297.101251. found: 297.101261.

Sources & evidence

ORD record
ord-68c5b54ce18a4e959f210a728e1d1a47
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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