4-({[2-(2,2-Dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-acetyl]-methoxyamino}-methyl)-benzoic acid methyl ester → HCID 76178827, compound

HRID 2214626Notes

Reaction equation

HRID 2214626 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([C:14](=[O:24])[CH:15]=[C:16]2[C:20](=[O:21])[O:19][C:18](C)(C)[O:17]2)[O:12][CH3:13])=[CH:6][CH:5]=1>CO>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([C:14](=[O:24])[CH:15]=[C:16]([OH:17])[C:20]([O:19][CH3:18])=[O:21])[O:12][CH3:13])=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 740584914-({[2-(2,2-Dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-acetyl]-methoxyamino}-methyl)-benzoic acid methyl ester

Product 1

HCID 76178827HCID 76178827, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-({[2-(2,2-Dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-acetyl]-methoxyamino}-methyl)-benzoic acid methyl ester was treated with methanol as described in the preparation of Compound 44-D and gave the title ester as a white solid. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.70 (3H, s, OCH3), 3.90 (3H, s, OCH3), 3.91 (3H, s, OCH3), 4.89 (2H, s, NCH2), 6.5 (1H, s, CH), 7.39 (2H, d, J=8.1 Hz, aromatics), 8.02 (2H, d, J=8.1 Hz, aromatics). HRMS (ES+) calculated for C15H18NO7, [M+H]+: 324.108327. found: 324.109066.

Workup

  1. customas described in the preparation of Compound 44-D

Sources & evidence

ORD record
ord-b90d1d15d5da4d27ac098c79039b74a3
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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