1-(4-Fluorophenyl)piperazine → HCID 54704629, compound

HRID 2214648Notes

Reaction equation

HRID 2214648 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:10][N:11]([CH2:16][CH:17](OC)OC)[C:12](=[O:15])[C:13]=1[OH:14])=[O:8].[F:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:10][N:11]([CH2:16][CH2:17][N:37]2[CH2:36][CH2:35][N:34]([C:31]3[CH:30]=[CH:29][C:28]([F:27])=[CH:33][CH:32]=3)[CH2:39][CH2:38]2)[C:12](=[O:15])[C:13]=1[OH:14])=[O:8]

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 54704627HCID 54704627, compound

Product 1

HCID 54704629HCID 54704629, compound

Procedure

Compound 748 was prepared from 1-(2,2-dimethoxy-ethyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3,4-dichloro-benzyl)-methyl-amide and 1-(4-fluoro-phenyl)-piperazine using the method described for compound 747. The title compound was isolated as an amber foam (0.009 g, 25% yield). HRMS (M+H) calcd for C24H28N4Cl2O3F: 521.15226. found: 521.1531.

Sources & evidence

ORD record
ord-80edfd1b7b8847958a70ab25df7ec0c4
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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