2,6-Dimethylmorpholine → HCID 54704626, compound

HRID 2214650Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:10][N:11]([CH2:16][CH:17](OC)OC)[C:12](=[O:15])[C:13]=1[OH:14])=[O:8].[CH3:27][CH:28]1[O:33][CH:32]([CH3:34])[CH2:31][NH:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:10][N:11]([CH2:16][CH2:17][N:30]2[CH2:29][CH:28]([CH3:27])[O:33][CH:32]([CH3:34])[CH2:31]2)[C:12](=[O:15])[C:13]=1[OH:14])=[O:8]

Participants

Reactant 2

HCID 1108622,6-Dimethylmorpholine

HCID 54704627HCID 54704627, compound

Product 1

HCID 54704626HCID 54704626, compound

Procedure

Compound 750 was prepared from 1-(2,2-dimethoxy-ethyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3,4-dichloro-benzyl)-methyl-amide and 2,6-dimethyl-morpholine using the method described for compound 747. The title compound was isolated as a pale yellow powder (0.014 g, 14% yield). HRMS (M+H) calcd for C21H28N3Cl2O4: 456.14570. found: 456.1472.

Sources & evidence

ORD record: ord-1b4a18ea975f4f9b8aacc65cf836d95d
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109186B2

Reaction notes

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