Formaldehyde → HCID 54704684, compound

HRID 2214675Notes

Reaction equation

HRID 2214675 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[S:20]([CH3:22])=[O:21])[CH3:11])=[O:9])[C:4](=[O:23])O1.[CH2:25]=O.[N:27]1([CH2:33][CH2:34][NH2:35])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([CH2:12][N:10]([CH3:11])[C:8]([C:7]2[CH2:25][N:35]([CH2:34][CH2:33][N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[C:4](=[O:23])[C:5]=2[OH:6])=[O:9])=[C:14]([S:20]([CH3:22])=[O:21])[CH:15]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 4082852-MorpholinoethylamineHCID 69655562HCID 69655562, compound

Product 1

HCID 54704684HCID 54704684, compoundYield 88%

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-2-methanesulfinyl-benzyl)-N-methyl-acetamide was reacted with paraformaldehyde and 2-morpholin-4-yl-ethylamine as described in Method 44 B to give the title compound as a yellow solid (0.04 g, 88% yield). 1HNMR (300 MHz, MeOD) δ: 7.72 (1H, dd, J=8.42, 2.56 Hz), 7.49 (1H, dd, J=8.79, 5.13 Hz), 7.32–7.26 (1H, m), 4.19 (2H, s), 4.09–3.46 (10H, m), 3.30–3.21 (2H, m), 3.12 (3H, s), 2.81 (3H, s).

Sources & evidence

ORD record
ord-d1e677c644734c8bb1e2f841223b23c5
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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