Hydrazine hydrate (1:1) → HCID 178509225, compound

HRID 2214737Notes

Reaction equation

HRID 2214737 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[N:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][C:6]=1[C:7]#[N:8]>N1C=CC=CC=1>[C:13]1([C:10]2[CH:9]=[C:6]3[C:7]([NH2:8])=[N:3][NH:2][C:5]3=[N:12][CH:11]=2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27640432-chloro-5-phenylnicotinonitrile

Product 1

HCID 178509225HCID 178509225, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Hydrazine hydrate (1.42 g, 28 mmol) was added to a stirred solution of 2-chloro-5-phenylnicotinonitrile (2.45 g, 11.4 mmol) in pyridine (25 ml). The reaction mixture was stirred at reflux for 6 hours, cooled and the resulting solid was filtered and dried in vacuo, affording the title compound as a solid.

Workup

  1. temperatureat reflux for 6 hours
  2. temperaturecooled
  3. filtrationthe resulting solid was filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-79f26bb2604840f29b7439d2cd3fb017
Source dataset
uspto-grants-2006_09
Patent number
US07109199B2

Reaction notes

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