HCID 21948263, compound → HCID 21948257, compound

HRID 2214749Notes

Reaction equation

HRID 2214749 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])=[CH:6][C:7]=1[C:8]([NH2:10])=O>P(Cl)(Cl)(Cl)=O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])=[CH:6][C:7]=1[C:8]#[N:10]

Participants

3

Reactant 1

HCID 21948263HCID 21948263, compound

Product 1

HCID 21948257HCID 21948257, compound

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

3-Chloro-6-(2,3-difluorophenyl)pyridazine-4-carboxamide (3.03 g, 11.2 mmol) was stirred in phosphoryl chloride (30 mL) at reflux for 3 hours, cooled, and evaporated to dryness. The residue was dissolved in dichloromethane, washed with saturated sodium hydrogen carbonate solution, dried (MgSO4) and evaporated to give the title compound as a solid.

Workup

  1. temperatureat reflux for 3 hours
  2. temperaturecooled
  3. customevaporated to dryness
  4. dissolutionThe residue was dissolved in dichloromethane
  5. washwashed with saturated sodium hydrogen carbonate solution
  6. dry with materialdried (MgSO4)
  7. customevaporated

Sources & evidence

ORD record
ord-a78a1bd1a73b4a478df2f642f59a4df4
Source dataset
uspto-grants-2006_09
Patent number
US07109199B2

Reaction notes

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