Hydrazine hydrate (1:1) → HCID 73855606, compound

HRID 2214750Notes

Reaction equation

HRID 2214750 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=2[F:17])=[CH:6][C:7]=1[C:8]#[N:9].O.[NH2:19][NH2:20]>C(O)C>[F:17][C:11]1[C:12]([F:16])=[CH:13][CH:14]=[CH:15][C:10]=1[C:5]1[CH:6]=[C:7]2[C:8]([NH2:9])=[N:4][NH:3][C:2]2=[N:19][N:20]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21948257HCID 21948257, compound

Product 1

HCID 73855606HCID 73855606, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Chloro-6-(2,3-difluorophenyl)pyridazine-4-carbonitrile (2.82 g, 11.2 mmol) and hydrazine hydrate (1.25 mL, 25.8 mmol) were stirred at reflux in ethanol (50 mL) for 1 hour. The mixture was cooled and evaporated to dryness. The residue was triturated with water, and the solid was filtered off and dried, giving the title compound as a solid.

Workup

  1. temperatureThe mixture was cooled
  2. customevaporated to dryness
  3. customThe residue was triturated with water
  4. filtrationthe solid was filtered off
  5. customdried

Sources & evidence

ORD record
ord-0c56c32809164ccca19c93e30f6a5858
Source dataset
uspto-grants-2006_09
Patent number
US07109199B2

Reaction notes

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