HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | cis-1-Acetyl-6-(3,5-dimethylpiperazin-1-yl)-5-methoxyindoline | HCID 69664906 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline | HCID 11265480 | 107.1% |
Reaction Steps
A stirred solution of D2 (1.6 g, 5 mmole) in 2M HCl acid (50 ml) was heated under reflux for 2 h, then allowed to cool, basified with K2CO3 and extracted with DCM. The extract was dried (Na2SO4) and concentrated under vacuum to afford the title compound as a pale orange solid (1.4 g, 100%). MH+ 276.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109201B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-7ddca317ee804d899f4ca913d4e9e9ca |
| Source note | uspto-grants-2006_09 |