HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → (E)-3-(dimethylamino)-1-(2-(methylthio)pyrimidin-4-yl)prop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1-[2-(Methylsulfanyl)pyrimidin-4-yl]ethan-1-one | HCID 11658348 | — |
| Product | (E)-3-(dimethylamino)-1-(2-(methylthio)pyrimidin-4-yl)prop-2-en-1-one | HCID 21948442 | — |
Reaction Steps
A solution of 1-[2-(methylthio)pyrimidin-4-yl]ethanone (1-3, 300 mg) in N,N-dimethylformamide dimethyl acetal (10 mL) was heated at 85° C. for16 hours. The mixture was concentrated to give (2E)-3-(dimethylamino)-1-[2-(methylthio)pyrimidin-4-yl]prop-2-en-1-one (1-4) as a yellow oil which crystallized upon standing. LRMS m/z: Calc'd for C10H14N3OS (M+H) 224.1. found 224.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109204B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-a0ce547ea63249128488fc157b0b6cc2 |
| Source note | uspto-grants-2006_09 |