Hydrochloric Acid → 2-Hydroxy-5-(methylsulfanyl)benzaldehyde

Temperature

90 °C

Ethyl magnesium bromide (38 mL of a 3.0 M solution in diethyl ether, 113.8 mmole) was chilled with an ice-water bath. To the chilled solution was added a solution of 4-(methylthio)phenol (15.95 g, 113.8 mmole) in diethyl ether (30 mL) over 0.15 hour during which time gas was evolved. The reaction was held at 0° C. for 0.5 hour, at room temperature for 0.5 hour, and the addition funnel replaced with a distillation head. Toluene (250 mL) and the diethyl ether were distilled out of the reactor. The reaction was cooled, toluene (250 mL) and hexamethylphosphoramide (HMPA) (19.8 mL, 20.4 g, 113.8 mmole) were added, and the resulting mixture was stirred for 0.25 hours. The distillation head was replaced with a condenser and paraformaldehyde (8.5 g, 284.4 mmole) was added. The reaction was heated to 90° C. for 3 hours. The reaction mixture was cooled to room temperature, was acidified with 1N HCl and the layers separated. The organic phase was washed with water, and with brine, dried over MgSO4, filtered, and concentrated in vacuo to yield a solid. This solid was purified by silica chromatography (hexanes-ethyl acetate, 5:1) yielding the salicylaldehyde as a yellow crystalline solid (6.01 g) of suitable purity to be used in the next reaction without further purification.

1. distillationToluene (250 mL) and the diethyl ether were distilled out of the reactor
2. temperatureThe reaction was cooled
3. customThe distillation head was replaced with a condenser
4. temperatureThe reaction mixture was cooled to room temperature
5. customthe layers separated
6. washThe organic phase was washed with water
7. dry with materialwith brine, dried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customto yield a solid
11. customThis solid was purified by silica chromatography (hexanes-ethyl acetate, 5:1)

ORD record

ord-4d2776ff41c5402db65de1b8679515b3

Source dataset

uspto-grants-2006_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07109211B2