Lithium Hydroxide → [Rac]-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid

HRID 2215221Notes

Reaction equation

C([O:3][C:4](=[O:30])[CH:5]([O:27][CH2:28][CH3:29])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]([CH3:25])([CH3:24])[CH3:23])[O:19][C:20]=2[CH3:21])=[CH:9][C:8]=1[CH3:26])C.[Li+].[OH-]>>[C:22]([C:18]1[O:19][C:20]([CH3:21])=[C:16]([CH2:15][CH2:14][O:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:27][CH2:28][CH3:29])[C:4]([OH:30])=[O:3])=[C:8]([CH3:26])[CH:9]=2)[N:17]=1)([CH3:24])([CH3:25])[CH3:23]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69486911[Rac]-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester

Product 1

HCID 11741056[Rac]-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid

Procedure

In analogy to the procedure described in example 46 d], [rac]-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester was treated with LiOH to obtain [rac]-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid as colorless liquid.

Workup

customdescribed in example 46 d

Sources & evidence

ORD record: ord-518bce47301149b98486125b00873076
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109225B2

Reaction notes

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