Lithium Hydroxide → HCID 69486698, compound

HRID 2215235Notes

Reaction equation

C[O:2][C:3](=[O:28])[C@@H:4]([O:25][CH2:26][CH3:27])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:20]([CH3:23])([CH3:22])[CH3:21])[O:17][C:18]=2[CH3:19])=[CH:8][C:7]=1[Cl:24].[Li+].[OH-]>>[C:20]([C:16]1[O:17][C:18]([CH3:19])=[C:14]([CH2:13][O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][C@H:4]([O:25][CH2:26][CH3:27])[C:3]([OH:28])=[O:2])=[C:7]([Cl:24])[CH:8]=2)[N:15]=1)([CH3:22])([CH3:23])[CH3:21]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69489456HCID 69489456, compound

Product 1

HCID 69486698HCID 69486698, compound

Procedure

In analogy to the procedure described in example 46 d], (S)-3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-2-chloro-phenyl]-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-2-chloro-phenyl]-2-ethoxy-propionic acid as colorless solid.

Workup

customdescribed in example 46 d

Sources & evidence

ORD record: ord-0092512dfd404f55beea9d3f4d61c26a
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109225B2

Reaction notes

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