Lithium Hydroxide → HCID 69487881, compound

HRID 2215240Notes

Reaction equation

C[O:2][C:3](=[O:29])[C@@H:4]([O:26][CH2:27][CH3:28])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:20]([CH3:23])([CH3:22])[CH3:21])[O:17][C:18]=2[CH3:19])=[CH:8][C:7]=1[O:24][CH3:25].[Li+].[OH-]>>[C:20]([C:16]1[O:17][C:18]([CH3:19])=[C:14]([CH2:13][O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][C@H:4]([O:26][CH2:27][CH3:28])[C:3]([OH:29])=[O:2])=[C:7]([O:24][CH3:25])[CH:8]=2)[N:15]=1)([CH3:21])([CH3:23])[CH3:22]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69489709HCID 69489709, compound

Product 1

HCID 69487881HCID 69487881, compound

Procedure

In analogy to the procedure described in example 46 d], (S)-3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-2-methoxy-phenyl]-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-2-methoxy-phenyl]-2-ethoxy-propionic acid as colorless liquid.

Workup

customdescribed in example 46 d

Sources & evidence

ORD record: ord-97c460ec758a44589018d5b2379114a3
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109225B2

Reaction notes

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