Lithium Hydroxide → HCID 69486710, compound

HRID 2215247Notes

Reaction equation

C[O:2][C:3](=[O:29])[C@@H:4]([O:26][CH2:27][CH3:28])[CH2:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]([CH3:24])([CH3:23])[CH3:22])[O:18][C:19]=2[CH3:20])=[CH:8][C:7]=1[CH3:25].[Li+].[OH-]>>[C:21]([C:17]1[O:18][C:19]([CH3:20])=[C:15]([CH2:14][O:13][C:9]2[CH:10]=[C:11]([CH3:12])[C:6]([CH2:5][C@H:4]([O:26][CH2:27][CH3:28])[C:3]([OH:29])=[O:2])=[C:7]([CH3:25])[CH:8]=2)[N:16]=1)([CH3:23])([CH3:24])[CH3:22]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69487613HCID 69487613, compound

Product 1

HCID 69486710HCID 69486710, compound

Procedure

In analogy to the procedure described in example 46 d], (S)-3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-2,6-dimethyl-phenyl]-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-2,6-dimethyl-phenyl]-2-ethoxy-propionic acid as colorless solid.

Workup

customdescribed in example 46 d

Sources & evidence

ORD record: ord-ae134f70641343679fc3aafd802c6cf1
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109225B2

Reaction notes

Loading…