Lithium Hydroxide → (S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid

HRID 2215249Notes

Reaction equation

HRID 2215249 reaction equation
C[O:2][C:3](=[O:30])[C@@H:4]([O:27][CH2:28][CH3:29])[CH2:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]([CH3:25])([CH3:24])[CH3:23])[O:19][C:20]=2[CH3:21])=[CH:8][C:7]=1[CH3:26].[Li+].[OH-]>>[C:22]([C:18]1[O:19][C:20]([CH3:21])=[C:16]([CH2:15][CH2:14][O:13][C:9]2[CH:10]=[C:11]([CH3:12])[C:6]([CH2:5][C@H:4]([O:27][CH2:28][CH3:29])[C:3]([OH:30])=[O:2])=[C:7]([CH3:26])[CH:8]=2)[N:17]=1)([CH3:24])([CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69489846(S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid methyl ester

Product 1

HCID 69486772(S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid

Procedure

In analogy to the procedure described in example 46 d], (S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid as colorless liquid.

Workup

  1. customdescribed in example 46 d

Sources & evidence

ORD record
ord-f07e9342b32f4e3881856eb0da9267ac
Source dataset
uspto-grants-2006_09
Patent number
US07109225B2

Reaction notes

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