Hydrogen Bromide → [2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile hydrobromide

HRID 2215853Notes

Reaction equation

HRID 2215853 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])[C:10]#[N:11].[BrH:19]>C(O)C>[BrH:19].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])[C:10]#[N:11]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 10858772[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile

Product 1

HCID 21953222[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile hydrobromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

13.8 g (0.05 mol) of [2-(2-thienyl)ethylamino](2-chlorophenyl)acetonitrile, prepared according to example 1. or 2., is dissolved in 30 ml of ethanol, to the solution 40 ml of 20% aqueous hydrogen bromide solution is added. The product which precipitates within a few minutes is collected, washed with ethyl acetate and then they are dried. Weight: 14 g (78.2%), mp.: 144–145° C. The product was identified by elementary analysis, IR spectrum and 1H-NMR investigation.

Workup

  1. additionis added
  2. customThe product which precipitates within a few minutes
  3. customis collected
  4. washwashed with ethyl acetate
  5. customthey are dried

Sources & evidence

ORD record
ord-ee9c20a443984d9aba4b2e3c8df5a590
Source dataset
uspto-grants-2006_09
Patent number
US07109356B2

Reaction notes

Loading…