反应详情

1-(2-Methylsulfanyl-phenyl)hydrazine hydrochloride (27 g, 141.9 mmol) and 4-piperidone monohydrate hydrochloride (21.8 g, 141.9 mmol) were dissolved in ethanol (350 mL) and heated at reflux for 45 min. Conc. HCl (30 mL) was added and heated at reflux for 12 h. The reaction was cooled to rt, filtered, washed with cold isopropyl alcohol (50 mL), and dried to give an off white solid, 6-methylsulfanyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride (33 g, 92%).

1. temperatureheated
2. temperatureat reflux for 45 min
3. temperatureheated
4. temperatureat reflux for 12 h
5. filtrationfiltered
6. washwashed with cold isopropyl alcohol (50 mL)
7. customdried