Piperidine → tert-butyl N-[4-[3-[2-(11-aminoundecanoylamino)-6-methylphenyl]phenyl]sulfonyl-5-methylsulfanylthiophene-2-carboximidoyl]carbamate

Participants

Reaction Steps

A solution of 50% piperidine in DMF [1 mL] was added to (10-{3′-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-ylcarbamoyl}-decyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (0.040 g, 0.043 mmol) [example 211, step a] and stirred for 0.5 hours, followed by evaporation. Column chromatography (10% MeOH in dichloromethane) of the residue yielded the title compound (0.024 g, 77%) as a solid. ESI-MS (m/z): Calcd. for C35H48N4O5S3: 700.28; found: 701.0.

Provenance & Evidence