Glycerol → Nabumetone

HRID 2216232Notes

Reaction equation

HRID 2216232 reaction equation
C[C@@H]([C@@H]1[C@@:12]2(C)[C@@H:13]([OH:28])[CH2:14][C@@H:15]3[C@@]4(C)C[CH2:22][C@@H:23](O)[CH2:24][C@H:19]4[CH2:18][CH2:17][C@@:16]3(C)[C@@H:11]2[CH2:10][CH2:9]1)CCC([O-])=O.[Na+].[OH:31][CH2:32]C(CO)O>>[CH3:12][C:13]([CH2:14][CH2:15][C:16]1[CH:11]=[CH:10][C:9]2[CH:22]=[C:23]([O:31][CH3:32])[CH:24]=[CH:19][C:18]=2[CH:17]=1)=[O:28]

Participants

3

Reactant 2

HCID 753GlycerolHCID 44582061sodium (4R)-4-[(3R,5R,8R,9R,10S,12S,13R,14S,17R)-3,12-dihydroxy-8,10,13-trimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate

Product 1

HCID 4409Nabumetone

Procedure

A weighed quantity of the drug material and a volume of a solution containing 2.2% Poloxamer 188, 0.1% sodium deoxycholate, and 2.2% glycerin adjusted to pH 8.7 were combined and mixed under high shear to form a pre-suspension. The pre-suspension was homogenized for 20 discrete passes at a pressure of 25,000 psi.

Workup

  1. additionmixed under high shear
  2. customto form a pre-suspension

Sources & evidence

ORD record
ord-a48ff31d725f444e8fafcf9955ae6f1a
Source dataset
uspto-grants-2006_09
Patent number
US07112340B2

Reaction notes

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