HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycerol → Nabumetone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycerol | HCID 753 | — |
| Reactant | sodium (4R)-4-[(3R,5R,8R,9R,10S,12S,13R,14S,17R)-3,12-dihydroxy-8,10,13-trimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate | HCID 44582061 | — |
| Product | Nabumetone | HCID 4409 | — |
Reaction Steps
A weighed quantity of the drug material and a volume of a solution containing 2.2% Poloxamer 188, 0.1% sodium deoxycholate, and 2.2% glycerin adjusted to pH 8.7 were combined and mixed under high shear to form a pre-suspension. The pre-suspension was homogenized for 20 discrete passes at a pressure of 25,000 psi.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112340B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-a48ff31d725f444e8fafcf9955ae6f1a |
| Source note | uspto-grants-2006_09 |