Sodium Hydroxide → HCID 21941648, compound

HRID 2216289Notes

Reaction equation

HRID 2216289 reaction equation
C([O:3][C:4](=[O:20])[C:5](=[O:19])[CH2:6][C:7]([C:10]1[C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8])C.[OH-].[Na+]>CO>[O:15]1[C:14]2[CH:13]=[CH:12][CH:11]=[C:10]([C:7]([CH3:9])([CH3:8])[CH2:6][C:5](=[O:19])[C:4]([OH:20])=[O:3])[C:18]=2[O:17][CH2:16]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 17989302Ethyl γ,γ-dimethyl-α-oxo-1,3-benzodioxole-4-butanoate

Product 1

HCID 21941648HCID 21941648, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

14.4 g of the thus obtained 4-(benzo[1,3]dioxol-4-yl)-4-methyl-2-oxo-pentanoic acid ethyl ester is stirred with 150 ml of 1 M sodium hydroxide and 300 ml of methanol for 10 hours at room temperature. The methanol is then removed in a vacuum, and the remaining solution is extracted with diethyl ether. The aqueous phase is acidified with 1 M hydrochloric acid and extracted with diethyl ether. After drying and concentration by evaporation, 11.1 g of 4-(benzo[1,3]dioxol-4-yl)-4-methyl-2-oxo-pentanoic acid is obtained as a yellowish oil.

Workup

  1. customThe methanol is then removed in a vacuum
  2. extractionthe remaining solution is extracted with diethyl ether
  3. extractionextracted with diethyl ether
  4. customAfter drying
  5. concentrationconcentration
  6. customby evaporation

Sources & evidence

ORD record
ord-d3a951e6e93e46bd8fb298b10e79293e
Source dataset
uspto-grants-2006_09
Patent number
US07112584B2

Reaction notes

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