Sodium Hydroxide → HCID 21941648, compound

Participants

Reaction Steps

14.4 g of the thus obtained 4-(benzo[1,3]dioxol-4-yl)-4-methyl-2-oxo-pentanoic acid ethyl ester is stirred with 150 ml of 1 M sodium hydroxide and 300 ml of methanol for 10 hours at room temperature. The methanol is then removed in a vacuum, and the remaining solution is extracted with diethyl ether. The aqueous phase is acidified with 1 M hydrochloric acid and extracted with diethyl ether. After drying and concentration by evaporation, 11.1 g of 4-(benzo[1,3]dioxol-4-yl)-4-methyl-2-oxo-pentanoic acid is obtained as a yellowish oil.

Provenance & Evidence